I have used formZ on a lot of systems as have my co-workers, and we have Never heard of this before BUT I made some suggestions for you yesterday. Did you try them?
Did you save your key shortcuts to a file? And when the stop working, does reloading them fix it?
And when your key shortcuts stop working, do they still show from the menu, or no? (Single key number key shortcuts are a really BAD idea because they will likely conflict with numeric input...)
Do you have your Scratch Disk set to System Defaults (vai Prefs) or are you changing that for some reason -- and if so, does not changing that help?
And did you install the latest driver for keyboard and mouse? Installing and managing your system on a Mac is pretty seamless - but something you need to do yourself on Windows.
Believe me, if anyone else had the problems you note, they would be posting the same thing but they are not. There can be a few quirky things with Workspaces, but what you report is NOT normal, and formZ does behave reliably on Windows, as well as Mac.
AND (oops, said that already before too) -- if you Save your preferred Workspace, does Reloading the Workspace (instead of deleting the autodessys folder) help?